I don't use my mouse for pc gaming when I play quake. I have rigged my .cfg file to cover most of the keyboard and can zip around the maps easily. I find using a mouse in some fps games limits a lot fo what you can do, especially with only one hand to manipulate the keyboard.
Most of my friends use the rebular axis planes for the mouse. Although I have one friend who inverts it and can do quite well on cs.
To each their own I suppose.